Evidence for a new paradigm of gonorrhoea transmission: Cross-sectional analysis of Neisseria gonorrhoeae infections by anatomical site in both partners in 60 male couples

VJ Cornelisse; D Williamson; L Zhang; MY Chen; C Bradshaw; JS Hocking; J Hoy; BP Howden; EPF Chow; CK Fairley

Journal article

Evidence for a new paradigm of gonorrhoea transmission: Cross-sectional analysis of Neisseria gonorrhoeae infections by anatomical site in both partners in 60 male couples

VJ Cornelisse, D Williamson, L Zhang, MY Chen, C Bradshaw, JS Hocking, J Hoy, BP Howden, EPF Chow, CK Fairley

Sexually Transmitted Infections | BMJ PUBLISHING GROUP | Published : 2019

DOI: 10.1136/sextrans-2018-053803

Abstract

Objective Gonorrhoea transmission between men is currently thought to occur primarily to and from the urethra. Transmission without urethral involvement, from throat-to-throat and throat-to-anus, is considered to be uncommon. Using gonorrhoea results from male couples, we aimed to investigate the transmission dynamics of gonorrhoea. If current medical consensus is correct, then most throat and anal infections should be explained by the partner's urethral infection. Methods This is a cross-sectional analysis of gonorrhoea diagnosed by nucleic acid amplification tests in both partners in male couples who attended Melbourne Sexual Health Centre together between March 2015 and June 2017. Isolate..

View full abstract

University of Melbourne Researchers

Deborah Williamson Author

Catriona Bradshaw Author

Jane Hocking Author

Ben Howden Author

Related Projects (3)

IMPROVING PREVENTION, TRACKING AND TREATMENT OF MAJOR HUMAN BACTERIAL PATHOGENS

This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause..

UNDERSTANDING, REDUCING AND PREVENTING COMMUNICABLE DISEASES USING APPLIED PATHOGEN GENOMICS

Infectious diseases are a major threat to human health. New molecular methods, particularly whole genome sequencing, promise a revolution in..

SEXUALLY TRANSMITTED INFECTIONS: CAUSES, CONSEQUENCES AND INTERVENTIONS

Sexually transmitted infections are important causes of serious illness and death in Australia and overseas with high or rising rates of tre..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) programme grant (no: 568971). EPFC is supported by the Early Career Fellowships from the NHMRC (no: 1091226). VJC is supported by a Research Training Scheme Scholarship from the Australian Government's Department of Education and Training. DW is supported by an Early Career Fellowships from the NHMRC (APP1123854). BPH is supported by a Practitioner Fellowship (GNT1105905). VJC had full access to all data in this study and takes final responsibility for the decision to submit for publication.